Monday, December 31, 2012

IPad app

Just a quick thought on the iPad app in development.

Often I access my mfi from within as well as without my network.

It would be great if we could have a primary and secondary server IP.

So that we can with minimal change or effort be able to access the mfi server on both a public and private IP depending on where we physically are located.
Sent from my AT100 using Tapatalk

Source: http://forum.ubnt.com/showthread.php?t=65883&goto=newpost

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Friday, December 28, 2012

You Can Take Pets Out On Quests In Fantasy Life | Siliconera

By Ishaan . December 26, 2012 . 11:40am

Tomorrow will see the release of Level 5?s Fantasy Life in Japan, and they?ve shared two more videos of the game in action. The first one shows the player interacting with their in-game pets, while the second shows off mining, followed by the creation of a weapon, and finally combat. Check them out below:

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Fantasy Life has illustrations by Yoshitaka Amano and music by Nobuo Uematsu. The game is being developed in collaboration with Brownie Brown, who were involved with the development of Mother 3.
You Can Take Pets Out On Quests In Fantasy Life



Video game stories from other sites on the web. These links leave Siliconera.

Source: http://www.siliconera.com/2012/12/26/you-can-take-pets-out-on-quests-in-fantasy-life/

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Study ties drug shortage to poorer cancer survival - Salt Lake Tribune

Young cancer patients who couldn?t get a key medicine because of a national drug shortage were more likely to suffer a relapse than others who were able to get the preferred treatment, doctors report. It?s the first evidence that a long-standing drug-supply problem probably has affected cancer treatment results in specific patients.

The study involved more than 200 children and young adults with a blood cancer called Hodgkin lymphoma. Like childhood leukemia, it can be cured nearly 80 percent of the time. But a drug shortage that has worsened since 2009 is threatening that success rate, doctors report in Thursday?s New England Journal of Medicine.

Hundreds of drugs, including sedatives, antibiotics, painkillers and cancer treatments, have gone in and out of short supply in recent years. Reasons include manufacturing and contamination problems, plant shutdowns, and fewer makers and lower profits for certain drugs, especially generics infused during surgery or cancer treatment.

Doctors sometimes substitute different drugs for ones in short supply. But proving that the swaps led to poorer results has been tough, especially for cancer patients whose disease and response to treatment vary so much.

"We really couldn?t put our finger on, did anybody really suffer?" said Dr. Michael Link, a cancer specialist at Stanford University and past president of the American Society of Clinical Oncology.

The new study, led by Dr. Monika Metzger of St. Jude Children?s Research Hospital in Memphis, gives the best evidence so far that patients are suffering.

It focused on mechlorethamine, or nitrogen mustard, a drug that has been in short supply until last month, when more became available. Doctors compared results among 181 Hodgkin lymphoma patients who received the drug to 40 others who were given a different chemotherapy, cyclophosphamide, when the first choice was unavailable.

Only 75 percent of those given the substitute drug stayed free of cancer for two years versus 88 percent who received the preferred treatment.

"We can think of no credible explanation for this dramatic difference" other than the drug substitution, the authors wrote.

No patients died, but those who relapsed were given more aggressive treatments, including stem-cell transplants that have more side effects and can harm fertility.

story continues below

One of them was Abby Alonzo, of Port St. Lucie, Fla. She was diagnosed with lymphoma three years ago, when she was 10. After eight weeks of treatment with the preferred drug, "she was doing wonderfully," said her mother, Katie Alonzo.

Then doctors said they were out of it.

"I said, what do you mean, we don?t have the medication my child needs?" Katie Alonzo said.

After four weeks on the substitute chemo, Abby?s cancer had returned and spread to more places, her mother said. The child received high doses of chemotherapy and radiation and now seems cancer-free, although the treatments damaged her lung capacity, leaving her short of breath.

"When your child has cancer you live day by day," and to find out a life-saving medicine isn?t available is "very, very frightening," Katie Alonzo said.

Copyright 2012 The Salt Lake Tribune. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.sltrib.com/sltrib/world/55530514-68/cancer-drug-treatment-patients.html.csp

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Wednesday, December 26, 2012

Peugeot manager rules out merger with GM's Opel: report

DEAR ABBY: While searching for two of my husband's childhood friends, with his knowledge, I believe I may have found a child he doesn't know is his. I'm not positive that the child is his, but the time frame and location indicate that he could be, and there's a strong resemblance to my husband's brother. (I have seen photos on the Internet.) I am curious whether my hunch is correct, but I'm afraid of asking the questions, not knowing how they would be received. My husband is a kind and caring person, a great husband and father. ...

Source: http://news.yahoo.com/peugeot-manager-rules-merger-gms-opel-report-095249953--sector.html

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Monday, December 24, 2012

Fat influences decisions taken by brain cells for production and survival

Dec. 23, 2012 ? Scientists at Karolinska Institutet in Sweden have identified two molecules that play an important role in the survival and production of nerve cells in the brain, including nerve cells that produce dopamine. The discovery, which is published in the journal Nature Chemical Biology, may be significant in the long term for the treatment of several diseases, such as Parkinson's disease.

The same scientists have previously shown that receptors known as "liver X receptors" or LXR, are necessary for the production of different types of nerve cells, or neurons, in the developing ventral midbrain. One these types, the midbrain dopamine-producing neurons play an important role in a number of diseases, such as Parkinson's disease.

What was not known, however, was which molecules stimulate LXR in the midbrain, such that the production of new nerve cells could be initiated. The scientists have used mass spectrometry and systematic experiments on zebrafish and mice to identify two molecules that bind to LXR and activate it. These two molecules are named cholic acid and 24,25-EC, and are bile acid and a derivate of cholesterol, respectively. The first molecule, cholic acid, influences the production and survival of neurons in what is known as the "red nucleus," which is important for incoming signals from other parts of the brain. The other molecule, 24,25-EC, influences the generation of new dopamine-producing nerve cells, which are important in controlling movement.

One important conclusion of the study is that 24,25-EC can be used to turn stem cells into midbrain dopamine-producing neurons, the cell type that dies in Parkinson's disease. This finding opens the possibility of using cholesterol derivates in future regenerative medicine, since new dopamine-producing cells created in the laboratory could be used for transplantation to patients with Parkinson's disease.

"We are familiar with the idea of cholesterol as a fuel for cells, and we know that it is harmful for humans to consume too much cholesterol," says Ernest Arenas, Professor of Stem Cell Neurobiology at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet, who led the study. "What we have shown now is that cholesterol has several functions, and that it is involved in extremely important decisions for neurons. Derivatives of cholesterol control the production of new neurons in the developing brain. When such a decision has been taken, cholesterol aids in the construction of these new cells, and in their survival. Thus cholesterol is extremely important for the body, and in particular for the development and function of the brain."

The study has been financed by grants from (among other bodies) the Swedish Brain Foundation, the European Union, the Swedish Foundation for Strategic Research, Karolinska Institutet and the Swedish Research Council.

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The above story is reprinted from materials provided by Karolinska Institutet.

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Journal Reference:

  1. Spyridon Theofilopoulos, Yuqin Wang, Satish Srinivas Kitambi, Paola Sacchetti, Kyle M Sousa, Karl Bodin, Jayne Kirk, Carmen Salt?, Magnus Gustafsson, Enrique M Toledo, Kersti Karu, Jan-?ke Gustafsson, Knut R Steffensen, Patrik Ernfors, Jan Sj?vall, William J Griffiths och Ernest Arenas. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nature Chemical Biology, 2012; DOI: 10.1038/nchembio.1156

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/xeZ3Z2ArdTY/121223152435.htm

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Friday, December 21, 2012

Iraq's president flown to Germany after stroke

Iraqi Presidential Office / EPA

Iraqi President Jalal Talabani (left), seen with Prime Minister Nuri al-Maliki on Dec. 17, has often mediated between Iraq's various factions.

By Reuters

BAGHDAD - Iraqi President Jalal Talabani has left a Baghdad hospital and is being transferred to Germany for treatment after suffering a stroke earlier this week, his office said Thursday.

The 79-year-old Kurdish statesman was admitted to hospital on Monday night.

He has often mediated among Iraqi Shiites, Sunnis and Kurds, and in a growing dispute over oil between Baghdad and the country's autonomous Kurdistan region.

"Treatment has allowed suitable conditions for his excellency to be transferred outside the country," the statement said, adding that Talabani's health had improved.

It was uncertain whether he would be able to return to his post, and his potential exit from politics is raising concerns about what could be a messy succession battle.

A year after the last U.S. troops left Iraq, the Arab-led central government and the Kurdish region are increasingly divided over oil and land in a rift that threatens to escalate into open conflict.

Iraq President Talabani 'stable' after stroke

Just days before he was hospitalized, Talabani had negotiated between Prime Minister Nouri al-Maliki?and Kurdistan authorities after both sent troops to face off along an internal border where they have laid rival claims to ethnically mixed territories.

A year after the last American troops left, the Arab-led central government and the Kurdish region are caught in a rift over oil and land that threatens to escalate into fighting.

One year after the U.S. military pullout, Iraq teeters between statehood and failure. NBC News' Jim Maceda reports.

Al-Maliki?and Kurdistan's leaders?have twice sent troops to the internal border where both lay claim to ethnically mixed territories dotted with oilfields.

Turkey is also embroiled in the dispute, angering Baghdad by talking about energy cooperation and oil pipelines that would give Kurdistan a route to export its own crude and effectively end its reliance on the central government's funds.

Blasts hit Iraq's Kirkuk, disputed territories

With oil majors such Exxon and Chevron now shifting their focus northward to sign deals with Kurdistan and away from Iraq's southern oilfields, leaders on both sides are warning of the risks of the dispute sliding into an ethnic war.

"If it erupts ... it will be a painful, shameful ethnic conflict," al-Maliki said warning of the risks following last month's military build-up around disputed towns.

At the heart of the dispute is the oil wealth under the swathe of land known as the "Disputed Territories" along the vague internal border that includes the ethnically mixed city of Kirkuk, known to some as the "Jerusalem of the Kurds.?

Baghdad has warned Exxon and other companies that deals struck with Kurdistan are illegal, a violation of what Iraqi officials see as a policy area that should be under central government control. The Kurds say the constitution's federalism guarantees their right to develop their region's oil resources.

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Copyright 2012 Thomson Reuters. Click for restrictions.

Source: http://worldnews.nbcnews.com/_news/2012/12/20/16037443-iraqs-president-talabani-leaves-for-treatment-in-germany-after-stroke?lite

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Thursday, December 20, 2012

Make Controller Layouts Right on an iPad: New Lemur Arrives, LiveControl 2.0 Soon [iOS; Gallery]

In-app editing, at last. Without switching to your Mac or PC, you can now edit or create layouts right on Lemur. Images courtesy Liine.

Once the layout is done, using an iPad as an interactive, do-anything-you-want, Star Trek-style music and visual controller is a unique pleasure. But as your fingers surf through virtual knobs and faders, the idea has surely occurred to you: why can?t I actually do my editing and layout on the iPad?

Lemur is perhaps the most powerful controller app anywhere, a terrific demonstration of why a tablet controller can be useful. And its editor ? directly descended from the editor that went with the original, pre-iPad Lemur hardware ? is powerful, unquestionably. But switching between an editor on the desktop and the layout on the tablet definitely feels less intuitive.

A Lemur update at last brings what users have wanted: now you can directly edit those layouts on the iPad (and iPhone/iPod touch), ideal for ?improvising? layouts and adjusting to what feels best on the controller. See the video for a first look. (One bonus, very interesting to a few of us: this also means, since you?re no longer tethered to the editor, you can more easily use Lemur as a controller with your Linux rig, whether that?s a laptop or a Raspberry Pi.)

It should be available on iTunes now. (Some country stores don?t get all updates immediately, so keep an eye out.)

That?s not all Lemur developers Liine are announcing today. Lemur also adds three new ?skins? for a bit more control over how your layouts look. And coming early next year, there will also be a free layout for Ableton Live from one of the best creators of this stuff, ST8. (I would expect this is tailored a bit to some of the subtle but significant controller changes in Live 9.)

The new Lemur ? in-app editing, new skins, and still the mobile controller app to beat.

Entirely tailored to iOS interface paradigms, in-app editing does everything you need to customize control layouts, says Liine. Here?s how they describe the use cases for the functionality:

So what does editing templates directly In-App mean?
For novice users, this means a much smaller learning curve and an immediate initial experience. Any basic configuration, such as a typical bank of faders, can now be created with a few familiar taps and gestures. And any factory template can be adjusted quickly to suit your particular needs.
?
For advanced users, the In-App Editor provides the possibility to quickly edit templates without breaking the musical flow. Whether you?re playing with live musicians or engineering a track in the studio, designing and using the Lemur controller becomes improvisatory. Need to add an extra fader for the reverb effect? Two seconds and you?ve got it.

We don?t know a whole lot about LiveControl 2.0, but knowing how powerful some of this stuff has been in the past ? and knowing ST8 was involved ? I expect hard-core Live users who love touch will be intrigued. (It?ll be interesting to stack this up against Ableton?s own Push, which should become available in roughly the same timeframe ? how you might choose one over another, or even use the two together.) What we have from Liine on what?s coming:

Experience the ultimate Ableton Live controller, designed in partnership with master designer ST8. Improvise a riff on the Play page, then switch to the Sequencer page to edit the pattern. Choose a key and scale to guide your melodies and use Quick Chord to instantly create harmonies. Use the Modulate page to flawlessly map any parameter from any plugin to the MultiBall object and take advantage of Physics, LFOs and gesture recording. The Launch page gives you everything you would expect from a clip launcher, and more. We even integrated snapshots and morphing. LiveControl 2 will be a free download available in early 2013.

Let?s have a look at the new releases in images:

The New Lemur

Some people may still prefer doing initial editing on the desktop app, but it?s hard to imagine anyone will complain about at last being able to make adjustments on mobile. And if you do want to start from scratch, you can do that, too. The new Lemur app, editing away.

You have complete access to widgets and parameters. And, as you can see, by using iOS-native UI components, Lemur makes sure those editing tasks are fat-finger-friendly.

LiveControl 2.0

A new Ableton Live controller template will be available as a free download early in 2013, says Liine.

Info on the updates:
http://liine.net/en/products/Lemur

http://liine.net

Source: http://createdigitalmusic.com/2012/12/make-controller-layouts-right-on-an-ipad-new-lemur-arrives-livecontrol-2-0-soon-ios-gallery/

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Tuesday, December 18, 2012

Tips On Making Your Home Based Business Successful | Jim ...

Mistakes Are Costing You! Learn To Stop?Making ALL 189 Of Them!

Struggling With WordPress? 100+ Step-By-Step Videos Now Available!

Posted by Administrator on Dec 17, 2012 in Uncategorized | Comments Off

There are thousands of men and women who have considered owning a successful work from home business. It is great to work for yourself, and work the hours you want. This is a good way to find a plan that works for you.

Try a side of comedy with your lunch! Laughing relaxes your muscles for up to 45 minutes, relieving both physical and mental stress. One way to tickle your funny bone and restore your enthusiasm for your work from home business is to take a look at some good online humor videos at YouTube or Laugh Or Die.

Membership fees can be a good way to collect some money from your customers and boost your profits. It?s often possible to create a subscription system that makes more profit for you and provides customers with valuable discounts or extras.

TIP! When you are involved in home business, you should know business-related transportation will be tax deductible. Business-related transportation costs are often tax deductible.

Personal Accounts

Make sure you have a separate business bank account. Do not use one account for your personal expenses and your business. Separating your business and personal accounts will make things a whole lot easier when tax season rolls around. You are much less likely to make mistakes on your taxes if your business and personal accounts are separate.

Social media is a great way to market a business, but make sure you do not neglect that in favor of socializing. Social media outlets such as Facebook are distracting and can entice you to waste a large amount of your time that you could be using to market your products. Socializing on Facebook is best saved for when working hours are finished.

TIP! Boost your website?s appearance and selling power to fuel the growth of your home business. Many people only promote their businesses with their sites, but you should sell your products and services on your site as well.

Make sure that you create some sort of objective for your business. It should be a short description of the goals for your business and should describe your business in just a few sentences. Be sure to keep this idea in mind, especially when you talk to someone about your company. Not only will it reinforce your own convictions, it will build confidence in others regarding your business.

Search Engine

Utilizing search engine optimization allows your website to climb to the top of the search engine rankings. This is one of the most critical factors in driving targeted traffic to your website. See how the top ranking sites are using SEO to improve their search engine results.

TIP! Choose a name with meaning. Your brand will represent your products, so having a creative name makes it easy for your clients to remember you.

You may want to hire an accountant for your tax and financial matters. Taking the time to learn about taxes can take time away from your work, lessening your profits.

You can use inexpensive, portable storage devices to keep copies of your business?s important information and records. Lost records can be disastrous and cost hundreds or thousands of dollars to restore. Mozy is another excellent option for backing up your computer.

Most of the supplies you will need to operate your work from home business can be found online at wholesale prices. The Internet offers access to a world of information; it also allows you to locate all of the supplies that you may need for reasonable prices. Gaining a business license will provide you discounts, as well as allow you more options on where you can purchase your supplies.

TIP! Having a supportive group can be very beneficial to running a home business. It helps to build a network with other peers.

When you start a new online business, you should look at the going market rate in your region. Use that information to establish your own rates. Set your prices at rates that will make you money.

You should set aside a percentage of all income earned towards your taxes. Your taxes are going to be roughly 20 percent of profits, and if you set aside when it is earned, you will not have problems when it comes time to pay.

When choosing a product to sell from home, find one that addresses one of your needs. Customers are sure to be interested in purchasing something with the ability to help with an issue they regularly confront. Come up with a product that solves a problem, and your business is likely to succeed.

TIP! It is more important to utilize your time and money on reliability testing for your website than to spend your resources on making it overly elaborate. Ensure that your webpage will load in all different places and on people?s phones, as well.

Always exercise patience. A home-based business is not going to flourish overnight. A home business will take both time and effort and you will see growth as you gain experience. You will need to remain patient and consistent as you are growing your business.

When working from home, try to always achieve your personal best. Even though it can be extremely fulfilling to have a home business, your self-esteem could suffer if you place work before your own needs. Take time to exercise, don?t snack too much and shower every morning. Doing these simple things can make you feel a lot better about yourself, and make you appear more professional to others as well.

As you can see, it will require a little bit of work and dedication to make the jump. If you can manage to pull through and stick to the plan, you will be able to accurately represent your dream in the company?s image and create something that is long-lasting and profitable over the years.

TIP! You must figure in cost, in order to know profit when you are selling items which you have made. Wholesale sellers often offer their products at twice the cost to make them.

Are you ready to have success in the home based business industry and build it on autopilot? Click below to register for free today. See how it works here. Also check out our team benefits here

Source: http://leucabiz.com/blog/tips-on-making-your-home-based-business-successful/

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Monday, December 17, 2012

Japan's LDP surges back to power, eyes two-thirds majority with ally

TOKYO (Reuters) - Japan's conservative Liberal Democratic Party (LDP) surged back to power in an election on Sunday just three years after a devastating defeat, giving ex-Prime Minister Shinzo Abe a chance to push his hawkish security agenda and radical economic recipe.

An LDP win will usher in a government committed to a tough stance in a territorial row with China, a pro-nuclear energy policy despite last year's Fukushima disaster and a potentially risky prescription for hyper-easy monetary policy and big fiscal spending to beat deflation and tame a strong yen.

A TV Asahi projection based on counted votes gave the LDP at least 291 seats in parliament's 480-member lower house, and together with its small ally, the New Komeito party, a two-thirds majority needed to override, on most matters, the upper house, where no party has majority.

That would help break a policy deadlock that has plagued the world's third biggest economy since 2007.

"We have promised to pull Japan out of deflation and correct a strong yen," Abe said on live television. "We need to do this. The same goes for national security and diplomacy."

Parliament is expected to vote Abe in as prime minister on December 26.

Analysts said that while markets had already pushed the yen lower and share prices higher in anticipation of an LDP victory, stocks could rise and the yen weaken further in response to "super majority."

While LDP and New Komeito officials confirmed they would form a coalition, LDP Secretary-General Shigeru Ishiba did not rule out cooperation with the Japan Restoration Party, a new right-leaning party that was set to pick up at least 52 seats.

"I think there is room to do this in the area of national defense," he said. The New Komeito is more moderate than the LDP on security issues.

DEMOCRATS' DEBACLE

Projections showed Prime Minister Yoshihiko Noda's Democratic Party of Japan winning at least 56 seats, less than a fifth of its tally in 2009. Noda said he was stepping down as party leader after the defeat, in which several party heavyweights lost their seats.

The Democrats swept to power in 2009 promising to pay more heed to consumers and break up the "iron triangle" of the powerful bureaucracy, business and politicians formed during more than half a century of almost unbroken LDP rule.

Many voters had said the DPJ failed to meet election pledges as it struggled to govern and cope with last year's huge earthquake, tsunami and nuclear disaster, and pushed through an unpopular sales tax increase with LDP help.

Voter distaste for both major parties has spawned a clutch of new parties including the Japan Restoration Party, founded by popular Osaka Mayor Toru Hashimoto.

LDP leader Abe, 58, who quit as premier in 2007 citing ill health after a troubled year in office, has been talking tough in a row with China over uninhabited isles in the East China Sea, although some experts and party insiders say he may temper his hard line with pragmatism once in office.

"The Senkaku islands are inherently Japanese territory," Abe said, referring to the islands that China calls the Diaoyu. "I want to show my strong determination to prevent this from changing."

But he also said he had no intention of worsening relations with China.

The soft-spoken grandson of a prime minister, who would become Japan's seventh premier in six years, Abe also wants to loosen the limits of a 1947 pacifist constitution on the military, so Japan can play a bigger global security role.

China's official Xinhua news agency, noting the deterioration in relations with Japan, warned it not to strain ties further.

"An economically weak and politically angry Japan will not only hurt the country, but also hurt the region and the world at large," Xinhua said. "Japan, which brought great harm and devastation to other Asian countries in World War Two, will raise further suspicions among its neighbors if the current political trend of turning right is not stopped in time."

"UNLIMITED" MONETARY EASING

The LDP, which promoted nuclear energy during its decades-long reign, is expected to be friendly to power utilities, although public safety concerns remain a barrier to business-as-usual for the industry.

Abe has called for "unlimited" monetary easing and big spending on public works to rescue the economy from its fourth recession since 2000. Such policies, a centerpiece of the LDP's platform for decades, have been criticized by many as wasteful pork-barrel politics.

Kyodo news agency said the new government could draft an extra budget for 2012/13 worth up to 10 trillion yen ($120 billion) and issue debt to pay for it.

Many economists say that prescription for "Abenomics" could create temporary growth and allow the government to go ahead with a planned initial sales tax rise in 2014 to help curb a public debt now more than twice the size of Japan's economy.

But it looks unlikely to cure deeper ills or bring lasting growth, and risks triggering a market backlash if investors decide Japan has lost control of its finances.

"Japan can't spend on public works forever and the Bank of Japan's monetary easing won't keep the yen weak for too long," said Koichi Haji, chief economist at NLI Research Institute. "The key is whether Abe can implement long-term structural reforms and growth strategies."

Japan's economy has been stuck in the doldrums for decades, its population ageing fast and flagship companies such as Sony Corp struggling with foreign rivals and burdened with a strong yen, making "Japan Inc" a synonym for decline.

(Additional reporting by Chikafumi Hodo, Yoko Kubota, Kiyoshi Takenaka, Leika Kihara and Mari Saito in TOKYO, Yoshiyuki Osada in OSAKA and Sui-Lee Wee in BEIJING; Editing by Tomasz Janowski and Robert Birsel)

Source: http://news.yahoo.com/japan-votes-election-seen-returning-ldp-power-000943156.html

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Friday, December 7, 2012

NASA investigates use of 'trailblazing' material for new sensors

ScienceDaily (Dec. 6, 2012) ? Tiny sensors -- made of a potentially trailblazing material just one atom thick and heralded as the "next best thing" since the invention of silicon -- are now being developed to detect trace elements in Earth's upper atmosphere and structural flaws in spacecraft.

Technologist Mahmooda Sultana, who joined NASA's Goddard Space Flight Center in Greenbelt, Md., two years ago and has since emerged as Goddard's go-to expert in the development of graphene-based technology, has expanded her portfolio to include two new research and development efforts aimed at creating nano-sized detectors that could detect atomic oxygen and other trace elements in the upper atmosphere and structural strains in everything from airplane wings to spacecraft buses.

"The cool thing about graphene is its properties," said Jeff Stewart, the acting assistant chief for technology for Goddard's Mechanical Systems Division. "It offers a plethora of possibilities. Frankly, we're just getting started."

Graphene, first discovered in 2004 by Russian-born scientists Andre Geim and Konstantin Novoselov, is just one atom thick and composed of carbon atoms arranged in tightly bound hexagons best visualized as atomic-scale chicken wire. Two hundred times stronger than structural steel, it not only is the strongest material ever measured, but also the most sensitive and stable at extreme temperatures, making it ideal for all types of uses. Since its discovery, hundreds of organizations worldwide have launched research efforts to take advantage of the material's unique properties.

Goddard is one in the growing contingent.

More than a year ago, Sultana and her team won research and development funding to set up production facilities and fine-tune processing techniques for fabricating graphene using a technique called chemical vapor deposition (CVD), a technique also used in manufacturing computer chips. With this approach, technicians place a metal substrate inside a vacuum chamber and inject gases that then react or decompose to produce the desired thin film.

Since then, the group has succeeded at manufacturing and processing relatively large, high-quality pieces of graphene, and is now ready to apply its expertise to advance other applications. "One of the most promising applications of this material is as a chemical sensor," Sultana said.

Chemical Sensors

She has teamed with retired Goddard scientist Fred Herrero, who is pursuing the research in an emeritus capacity, to develop a miniaturized, low-mass, low-power, graphene-based detector that could measure the amount of atomic oxygen in the upper atmosphere. Atomic oxygen in the upper atmosphere is created when ultraviolet radiation from the sun breaks apart oxygen molecule (O2). The resultant reactive element is highly corrosive. As satellites fly through the upper atmosphere, the chemical strikes them at about five miles per second. The impacts destroy commonly used spacecraft materials, such as Kapton.

Although scientists believe atomic oxygen makes up 96 percent of the thin atmosphere in low-Earth orbit, Herrero is interested in measuring its density and determining more precisely its role in creating atmospheric drag, which can cause orbiting spacecraft to lose altitude prematurely and plunge to Earth. "We still don't know the impact of atomic elements on spacecraft in creating a drag force," he said. "We don't know how much momentum is transferred between the atom and the spacecraft. This is important because engineers need to understand the impact to estimate the lifetime of a spacecraft and how long it will take before the spacecraft reenters Earth's atmosphere."

Research has shown that graphene-based sensors offer a good solution, Sultana said. When graphene absorbs atomic oxygen, it oxidizes, producing a change in the material's electrical resistance that a graphene-based sensor could then quickly count to produce a more accurate density measurement. "I'm really excited about this material's possibilities," Herrero said, adding that graphene would greatly simplify the steps needed to measure atomic oxygen. "We'd be counting how often the resistance changes."

Atomic oxygen isn't the only element the chemical sensor could measure, Sultana said. She also believes it's ideal for measuring methane, carbon monoxide, and other gases on other planetary bodies and monitoring outgassing that sometimes contaminates instrument optics. She plans to fabricate and test the first generation of graphene-based chemical sensors by the end of the fiscal year, she said. "This is at a very early stage," Sultana added.

Strain Detection

Graphene's unique attributes also make it a viable candidate for detecting stresses in spacecraft components, she said. With her collaborators at the Massachusetts Institute of Technology (MIT), the team is using support from NASA's Office of the Chief Technologist to advance a small sensor that could be embedded in spacecraft materials, including composites. If the material underwent some type of stress, the tiny sensors would detect it.

The team has used CVD to manufacture and test a large piece of graphene, whose electrical properties are sensitive to detecting stresses, Sultana said. Her MIT collaborators now are fabricating graphene devices and her team is wiring them to read out measurements -- much like the medical electrodes used for certain medical tests. However, Sultana plans to eliminate the wiring so that it operates autonomously, she said.

"This could be deployed in a non-invasive way," Stewart said. "Right now, we use relatively large devices to detect damage or potential sources of failure, but with autonomous graphene-based sensors our hope is that we could put them into the material itself."

"We can employ a different combination of its extreme properties and use the same material for different sensing applications," Sultana added. "That's the beauty of graphene."

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Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/bJp1OevyNQY/121206104548.htm

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Thursday, December 6, 2012

Texas cancer agency exec: Mistakes led to grant

AUSTIN, Texas (AP) -- The chief executive of Texas' embattled $3 billion cancer-fighting agency on Wednesday defended his job while explaining to a state board how a private company improperly received $11 million in the second questionable award to embarrass the agency this year.

Bill Gimson, the Cancer Prevention and Research Institute of Texas' first and only executive director, took blame for Dallas-based Peloton Therapeutics receiving the lucrative taxpayer-funded grant even though the company's proposal was never scrutinized. He chalked it up as an honest mistake and said there was no evidence that agency staff stood to personally benefit financially from Peloton.

But one member of the agency's governing board ? made up of political appointees of Gov. Rick Perry, the lieutenant governor and House speaker? requested that Gimson face a job review.

CPRIT's problems began in May when questions arose over a separate $20 million grant that was also insufficiently reviewed, and led to dozens of agency peer reviewers resigning in protest.

Tom Luce, a Dallas attorney appointed to the board this year, said the board had counted on Gilman to make sure rules were followed.

"I'm certain they felt like they were relying on you (to have) sufficient processes in place to assure something like this did not happen," Luce said.

CPRIT has spent the year mired in criticism and intensifying scrutiny after debuting in 2009 to widespread acclaim. The unprecedented state-run agency is home to the nation's second largest pot of cancer-research money, behind only the National Institutes of Health, and has awarded nearly $700 million.

An internal audit uncovered the irregularities surrounding Peloton's award in 2010. The agency says the company was unaware its 27-page proposal was never reviewed, and company executives have declined comment.

All grants must ultimately be approved by the agency's governing board. Gimson said Peloton's proposal wound up in front of that panel because Jerry Cobbs, the agency's former chief commercialization officer, mistakenly thought he was submitting a request to perform "due diligence" on the company. Instead, believing that Cobbs was recommending Peloton for funding, the board voted in 2010 to give Peloton $11 million, according to Gimson.

Gimson did not explain why Cobbs never corrected the board's action. Cobbs resigned from the agency last month, and attempts to reach him have been unsuccessful.

Gimson told board members Wednesday that the lapse in checks and balances occurred during the agency's infancy, when rules were still being put in place.

"It was a procedural nightmare," Gimson said.

According to the agency's internal audit, emails between Cobbs and former chief science officer Dr. Alfred Gilman about Peloton are no longer available. Neither a report from the agency's compliance officer nor a letter Gimson wrote to lawmakers this week explains why.

Peloton has so far received $3.2 million from the state. The rest of the funding had been frozen pending a review of the company's application.

James Mansour, chairman of the oversight board, said the Peloton discovery has been "embarrassing." He said he would have difficulty approving the company for funding without more assurance that Peloton does not have ties to agency officials.

___

Follow Paul J. Weber on Twitter: www.twitter.com/pauljweber

Source: http://news.yahoo.com/texas-cancer-agency-exec-mistakes-000336603.html

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Wednesday, December 5, 2012

Quotations of the day

Please check the URL for proper spelling and capitalization. If you're having trouble locating a destination on Yahoo!, try visiting the Yahoo! homepage or look through a list of Yahoo!'s online services.

Please try Yahoo Help Central if you need more assistance.

Source: http://news.yahoo.com/quotations-day-070627283.html

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Tuesday, December 4, 2012

Awkward Photos: Dads On Vacation Edition (PHOTOS)

The weather outside hasn't quite hit frightful levels yet, but the chillier temperatures and upcoming holidays have us thinking about vacations here at Huff/Post50. Specifically the awkward photos that get taken during vacation, featuring incredibly eager husbands and fathers mugging for the camera.

Clarke Joyner of Dads on Vacation was kind enough to share some of these incredibly hilarious photos of dads being anything but cool on vacation. These pops haven't met a bronzed animal with gaping jaws or stuffed bear they didn't like, embarrassing their families and posing their ways into our hearts.

Check out the slideshow below for some of the most awkward photos on the site.

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Source: http://www.huffingtonpost.com/2012/12/03/awkward-photos-dads-on-vacation-tumblr_n_2007572.html

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Thursday, November 29, 2012

Former baseball union head Miller dead at 95

NEW YORK (AP) ? Marvin Miller was a labor economist who never played a day of organized baseball. He preferred tennis. Yet he transformed the national pastime as surely as Babe Ruth, Jackie Robinson, television and night games.

Miller, the union boss who won free agency for baseball players in 1975, ushering in an era of multimillion-dollar contracts and athletes who switch teams at the drop of a batting helmet, died Tuesday at 95. He had been diagnosed with liver cancer in August.

"I think he's the most important baseball figure of the last 50 years," former baseball Commissioner Fay Vincent said. "He changed not just the sport but the business of the sport permanently, and he truly emancipated the baseball player ? and in the process all professional athletes. Prior to his time, they had few rights. At the moment, they control the games."

In his 16 1/2 years as executive director of the Major League Players Association, starting in 1966, Miller fought owners on many fronts, not only achieving free agency but making the word "strike" stand for something other than a pitched ball.

Over the years, his influence was widely acknowledged if not always honored. Baseball fans argue over whether he made the game fairer or more nakedly mercenary, and the Hall of Fame repeatedly rejected him in what was attributed to lingering resentment among team owners.

Players attending the union's annual executive board meeting in New York said their professional lives are Miller's legacy.

"Anyone who's ever played modern professional sports owes a debt of gratitude to Marvin Miller," Los Angeles Dodgers pitcher Chris Capuano said. "He empowered us as players. He gave us ownership of the game we play. Anyone who steps on a field in any sport, they have a voice because of him."

Major League Baseball's revenue has grown from $50 million in 1967 to $7.5 billion this year. At his last public speaking engagement, a discussion at New York University School of Law in April marking the 40th anniversary of the first baseball strike, Miller said free agency and resulting fan interest contributed to the increase. And both management and labor benefited, he said.

"I never before saw such a win-win situation in my life, where everybody involved in Major League Baseball, both sides of the equation, still continue to set records in terms of revenue and profits and salaries and benefits," Miller said. He called it "an amazing story."

Miller, who retired in 1982, led the first walkout in the game's history 10 years earlier, a fight over pension benefits. On April 5, 1972, signs posted at major league parks simply said: "No Game Today." The strike, which lasted 13 days, was followed by a walkout during spring training in 1976 and a midseason job action that darkened the stadiums for seven weeks in 1981.

Miller led players through three strikes and two lockouts. Baseball has had eight work stoppages in all.

Slightly built and silver-haired with a thick, dark mustache, Miller operated with an eloquence and a soft-spoken manner that belied his toughness. He clashed repeatedly with Commissioner Bowie Kuhn.

Before Miller took over the union, some players actually opposed his appointment as successor to Milwaukee Judge Robert Cannon, who had counseled them on a part-time but unpaid basis.

"Some of the player representatives were leery about picking a union man," Hall of Fame pitcher and former U.S. Sen. Jim Bunning said in 1974. "But he was very articulate ... not the cigar-chewing type some of the guys expected."

Miller recalled that owners "passed the word that if I were selected, goon squads would take over the game. They suggested racketeers and gangsters would swallow baseball. The players expected a 'dese, dem and dose' guy. The best thing I had going for me was owner propaganda."

He was elected by the players by a vote of 489-136. Baseball had entered a new era, one in which its owners would have to bargain with a union professional.

When he took over, the union consisted of a $5,400 kitty and a battered file cabinet, and baseball's minimum salary was $6,000. By 1968, Miller had negotiated baseball's first collective bargaining agreement. By 1970, players obtained the right to take disputes to an arbitrator.

Nowadays, baseball's biggest stars make up to $32 million a season, the average salary is more than $3 million and the major league minimum is $480,000. While the NFL, NBA and NHL have salary caps, baseball does not.

Miller's biggest legacy ? free agency ? represented one of the most significant off-the-field changes in the game's history. The reserve clause that had been in place since 1878 bound a player to the team holding his contract. Miller viewed it as little more than 20th-century slavery.

"Before Marvin, there were no such things as the negotiations. It was take it or leave it," Hall of Famer Joe Morgan said. "What was your recourse, to quit?"

Acting with union backing, outfielder Curt Flood finally challenged the reserve clause when he refused to report to his new team when he was traded in 1969 from the St. Louis Cardinals to the Philadelphia Phillies. Three years later, the U.S. Supreme Court upheld the reserve clause by a 5-3 vote, keeping intact baseball's antitrust exemption.

In 1975, however, the union found a new test case, when pitchers Andy Messersmith and Dave McNally refused to re-sign with the Los Angeles Dodgers and the Montreal Expos, respectively. Arbitrator Peter Seitz sided with the players.

The owners went to court, saying the reserve system was not subject to arbitration. Two months later, U.S. District Judge John Watkins Oliver upheld Seitz, and a federal appeals court did the same.

In 1976, management and labor agreed to a contract that allowed players with six years of major league service to become free agents and sell their services to any team willing to pay. In a 1982 letter to The New York Times, Seitz called Miller "the Moses who had led Baseball's Children of Israel out of the land of bondage."

"Marvin possessed a combination of integrity, intelligence, eloquence, courage and grace that is simply unmatched in my experience," said Donald Fehr, a successor to Miller as union head. "Without question, Marvin had more positive influence on Major League Baseball than any other person in the last half of the 20th century."

Yet baseball's Hall of Fame refused to vote him in, despite five appearances on the ballot.

"I and the union of players have received far more support, publicity and appreciation from countless fans, former players, writers, scholars, experts in labor management relations, than if the Hall had not embarked on its futile and fraudulent attempt to rewrite history," Miller said after falling one vote shy in 2010. "It is an amusing anomaly that the Hall of Fame has made me famous by keeping me out."

Miller's next opportunity for election is December 2013.

Former Commissioner Peter Ueberroth said Miller should be inducted "without question."

"He changed the game of baseball," Ueberroth said. "He was very tough, but he was very fair in the end."

Miller was born in New York, the son of a salesman in the heavily unionized garment district. He was born with a withered right arm, which didn't prevent him from playing tennis into his 90s. His mother was a schoolteacher. He studied economics at Miami University in Ohio and New York University.

He entered the labor field in 1950 as an associate director of research for the United Steelworkers Union. In 1960, he was promoted to assistant to union president David McDonald. When McDonald lost a hotly contested election, Miller began looking for a new job.

Miller remained current on baseball events right up until his death, never hesitating to criticize owners for collusion and the union for agreeing to drug testing.

While baseball has had labor peace since 1995, turmoil has engulfed the other major U.S. pro leagues in recent years.

"Marvin exemplified guts, tenacity and an undying love for the players he represented," said DeMaurice Smith, head of the NFL players union. "He was a mentor to me, and we spoke often and at length. His most powerful message was that players would remain unified during labor strife if they remembered the sacrifices made by previous generations."

Miller is survived by his daughter, Susan; son, Peter; and a grandson. His wife, Terry, died in 2009. Susan Miller said her father wanted his body donated to science. She said the family had not decided whether to hold a service.

___

AP Baseball Writer Ben Walker contributed to this report.

Source: http://news.yahoo.com/former-baseball-union-head-miller-dead-95-153136375--mlb.html

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Wednesday, November 28, 2012

What are the Benefits of an LLC? | Entrepreneurship Advancement ...

By Janet Monroe, Attorney
Brannon Robinson PC

When launching a new business, you may want to consider the formation of a limited liability company.? Among other advantages, an LLC offers flexibility, can prove less costly to maintain, and provides the combined benefits of limited liability protection of a business entity, along with flow-thru taxation of a partnership.

Limited-Liability Protection

As opposed to operating as a sole proprietor or in a general partnership, setting up your start-up as a separate business entity such as a C-corporation, S-corp or LLC, gives you (and each of your business partners) a layer of protection against personal liability.

The process of forming either a corporation or LLC is relatively similar.? Generally, there are five steps to create a new start-up LLC:

  1. File the Articles of Organization with the Secretary of State
  2. Register?the entity with the Internal Revenue Service to obtain an Employer?Identification Number (EIN)
  3. Open?a business bank account (take your approved Articles and EIN with you)
  4. Formalize?the terms between you and your business partners with a written Operating?Agreement
  5. Affirm?the formation of the entity in writing with formal Resolutions

Once you have accomplished all of the above,? your start-up is ready for the ribbon cutting ceremony and to begin its business operations.

Please note, however, that your limited liability protection is not absolute.? You must maintain your business affairs separately from your personal finances and assets.? Be sure to open up your business banking account with a deposit of your start-up capital investment.? Be careful not to commingle your personal assets with your business assets or you? run the risk of losing the limited liability protection of the entity ? commonly known as ?piercing the corporate/LLC veil.?

Low-Maintenance

Limited liability companies are for the most part low-maintenance on the record-keeping end of things.? Once you have your formation documents, you should keep them organized in an official Minute Book.? Should you make any changes to the terms, make sure to document them in writing.

This is where you may begin to see your cost savings.? In comparison to corporations, your needs for ongoing legal documentation will likely be minimal because the regulations for maintaining a limited liability company are much less rigid.? Corporate formalities such as holding annual meetings, keeping detailed records of those meetings and any major business decisions require ongoing legal documentation in order to properly maintain your company?s Minute Book.

These formalities are not required for LLCs, and thus lower ongoing legal fees as well as make it much more difficult to ?pierce the veil? of an LLC by not having to keep up with formal corporate-type requirements.

Flexibility

Perhaps the most important benefit of a limited liability company is the flexibility that it allows in choosing accounting methods, your management structure, and allocating profit-sharing amongst its members.? State statutes leave such provisions up to the members of the LLC by allowing such terms to be defined within its operating agreement.

Flow-Through Taxation

Finally, with an LLC, income is not taxed at the entity level, rather it ?flows through? to the business partners of the company and income and expenses are reported on the individual?s tax returns either as a sole proprietor or as a partnership. ?You?ll want to speak with an accountant in detail about this, because the ability to claim the initial years of start-up losses on your individual tax returns, for instance, could prove to be quite beneficial to you.

Additionally, you can elect for your LLC to be taxed as a C-corporation or S-corporation. Combining an LLC entity with the self-employment tax benefits of an S-corporation election is an ideal single member LLC, especially when the business is involved in the business of real estate.

If you are thinking about setting up a start-up, you should keep limited liability companies in mind.? Seek advice from both an attorney and an accountant before you decide which entity type would be best for your particular needs.

?

This blog is provided for informational purposes only. ?All information contained should not be considered legal advice, nor should you take action upon this information without first seeking professional counsel. If you decide to comment or contact an attorney by any means of communication, do not disclose information you regard as confidential. ?Unless otherwise agreed in advance, all unsolicited inquiries or information received by Brannon Robinson PC will not be regarded as confidential. and no attorney/client relationship is formed by means of Internet or digital communication.

Source: http://goentrepreneurs.org/2012/11/what-are-the-benefits-of-an-llc/

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Tuesday, November 27, 2012

Disney?s new robot plays catch with your kids

11 hrs.

For better ? or worse ? the research lab side of Disney is building a robot that plays a decent game of catch, meaning parents can keep their eyes on Facebook while their kids get a bit of exercise.

The robot has a human-like appearance and uses a Microsoft Kinect to track the balls. After a few practice tosses, almost anyone can successfully play catch with it.

The humanoid is intended to give theme-park visitors a means to interact with robots without actually touching them and accidently causing thousands of dollars? worth of damage, according to the Disney Research video below explaining the project.?

The robot is programmed to turn its head, giving the impression it is maintaining body presence with its playmate and tracking the ball with its eyes. When it misses a bad toss, the robot moves its head as if looking for the lost ball or bowing in embarrassment. Other times, it just shrugs its shoulders.

Importantly, there are no temper tantrums or rants about lost scholarship opportunities. Instead, the robot keeps playing, entertaining the old fashioned way, with a twist of the future thrown in for good measure.

?? via Mashable?

John Roach is a contributing writer for NBC News Digital. To learn more about him, check out his website. For more of our Future of Technology series, watch the featured video below.

Source: http://www.nbcnews.com/technology/futureoftech/disneys-new-robot-plays-catch-your-kids-1C7206759

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Friday, November 23, 2012

Key events early in process of cellular aging defined

ScienceDaily (Nov. 21, 2012) ? For the first time, scientists at Fred Hutchinson Cancer Research Center have defined key events that take place early in the process of cellular aging. Together the discoveries, made through a series of experiments in yeast, bring unprecedented clarity to the complex cascade of events that comprise the aging process and pave the way to understanding how genetics and environmental factors like diet interact to influence lifespan, aging and age-related diseases such as cancer and neurodegenerative disorders.

The findings, including unexpected results that link aspects of aging and lifespan to a mechanism cells use to store nutrients, are described in the Nov. 21 issue of Nature by co-authors Daniel Gottschling, Ph.D., a member of the Hutchinson Center's Basic Sciences Division, and Adam Hughes, Ph.D., a postdoctoral fellow in the Gottschling Lab.

The researchers found the acidity of a structure in yeast cells known as the vacuole is critical to aging and the functioning of mitochondria -- the power plants of the cell. They also describe a novel mechanism, which may have parallels in human cells, by which calorie restriction extends lifespan.

The work began with Hughes and Gottschling searching for the source of age-related damage in mitochondria.

"Normally, mitochondria are beautiful, long tubes, but as cells get older, the mitochondria become fragmented and chunky," said Gottschling, also an affiliate professor in the Department of Genome Sciences at the University of Washington. "The changes in shape seen in aging yeast cells are also observed in certain human cells, such as neurons and pancreatic cells, and those changes have been associated with a number of age-related diseases in humans."

What causes mitochondria to become distorted and dysfunctional as cells age had long been a mystery, but Gottschling and Hughes have discovered that specific changes in the vacuole lead directly to their malfunctioning.

The vacuole -- and its counterpart in humans and other organisms, the lysosome -- has two main jobs: degrading proteins and storing molecular building blocks for the cell. To perform those jobs, the interior of the vacuole must be highly acidic.

Hughes and Gottschling found that the vacuole becomes less acidic relatively early in the yeast cell's lifespan and, critically, that the drop in acidity hinders the vacuole's ability to store certain nutrients. This, in turn, disrupts the mitochondria's energy source, causing them to break down. Conversely, when Hughes prevented the drop in vacuolar acidity, the mitochondria's function and shape were preserved and the yeast cells lived longer.

"Until now, the vacuole's role in breaking down proteins was thought to be of primary importance. We were surprised to learn it was the storage function, not protein degradation, that appears to cause mitochondrial dysfunction in aging yeast cells," Hughes said.

The unexpected discovery prompted Hughes and Gottschling to investigate the effects of calorie restriction, which is known to extend the lifespan of yeast, worms, flies and mammals, on vacuolar acidity. They found that calorie restriction -- that is, limiting the raw material cells need -- delays aging at least in part by boosting the acidity of the vacuole.

"Now that we have preliminary evidence in yeast of how calorie restriction extends lifespan, our hope is that it can be translated to higher organisms like humans," Hughes said. Given the similarities in the fundamental biology of yeast and human cells, the researchers' newly defined link between what cells "eat" and how they age could shed valuable light on the events that lead to age-related disorders in humans.

"There has been a lot in the scientific literature and the general media lately about how what you eat affects the aging process, but it has been incredibly confusing. Now we have a new paradigm for understanding how genetics and environment interact to influence lifespan, aging and age-related diseases. That's what I'm really excited about," Gottschling said.

Gottschling and Hughes speculate that if the vacuole's declining acidity limits its ability to store certain nutrients and metabolites, they may build up in the cell, flooding the mitochondria. Overwhelmed, the mitochondria use up all their energy -- essentially burning out their motors -- taking in the surplus. With no power left to import the proteins they need to maintain their elegant shape and execute their regular duties, the mitochondria literally break down. Gottschling and his colleagues are now investigating this hypothesis in detail. They are also exploring what triggers the initial drop in the vacuole's acidity.

The latter research question is of particular interest because the researchers found that even though vacuolar acidity drops as mother yeast cells age, the acidity in the vacuoles of their newborn daughter cells is normal. This corresponds to previous findings in the field that all daughter yeast cells have the same potential lifespan, regardless of the age of their mothers. The resetting of the daughter's vacuolar acidity is the earliest event yet observed in cellular rejuvenation, a phenomenon in which age-related defects are seemingly erased in an organism's offspring. This could help explain how the act of cell division itself contributes to aging.

These results are just the newest chapter in a "decade-old interest," according to Gottschling. He and his colleagues have made several landmark discoveries in the past 10 years, including finding that aging yeast cells exhibit the same genomic instability seen in human cancer cells and proving that mitochondrial dysfunction causes that instability. Gottschling's team also has developed innovative tools to leverage the power of yeast as a model organism, including a technique called the Mother Enrichment Program that makes experiments more efficient by enabling researchers to generate large populations of aging yeast cells.

"It's worth using yeast to study complex things like aging because a lot of person-years of research have gone into understanding the fundamentals. The genetic and cell-biology tools available for studying yeast are unparalleled," Gottschling said. "Having the proper tools is like having new glasses; you can see things you never could before, and once you start to see new things, you can dissect them to understand how they work."

In addition to the latest eye-popping technology, the researchers relied on sheer tenacity -- with a little help from motion-sickness pills -- in pursuit of their discoveries. Some of the painstaking experiments required Hughes to delicately manipulate individual yeast cells as they divided every two hours for days at a time. For another series of experiments that lasted several months, Hughes took Dramamine to ward off the queasiness that came with inspecting brightly colored yeast cells as they streaked across his microscope's field of view.

"There were definitely tough points, but it was worth it when we knew the story as a whole. Showing that the change in vacuolar acidity was real and that it mattered -- that it affected lifespan -- made the grueling experiments worthwhile," Hughes said. Gottschling is an elected member of the National Academy of Sciences, the American Academy of Arts & Sciences, the Washington State Academy of Sciences and the American Academy of Microbiology.

This research was funded by grants from the National Institutes of Health, the Helen Hay Whitney Foundation, a University of Washington's Genetic Approaches to Aging Training Grant and the Glenn Foundation for Medical Research. Preliminary support, including for the development of technologies used in this research, was provided by the Hutchinson Center's Hartwell Innovation Fund.

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The above story is reprinted from materials provided by Fred Hutchinson Cancer Research Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Adam L. Hughes, Daniel E. Gottschling. An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature, 2012; DOI: 10.1038/nature11654

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/y5kyCEdwqp8/121121145404.htm

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NO PROPERTY TAX UNDER OUR BUDGET PROPOSALS, SAYS ...

Donegal Fianna F?il TD Charlie McConalogue has said there is no need to hit hard-pressed homeowners with a property tax in next year?s budget.

Fianna F?il launched its alternative budget for 2013 this week, proposing a full reversal of controversial cuts to home help hours and vowing to protect frontline education services.

The proposals, which have been fully costed by the Department of Finance, will reach the target of ?3.5 billion in savings next year through an even split of taxation and expenditure measures.

But Deputy Charlie McConalogue said it?s about a fairer way towards recovery, instead of expecting hard-pressed families and the most vulnerable people to bear the brunt of the burden.

The Donegal TD explained, ?We are proposing that education, mental health and disability services be fully protected. This means reversing the deeply unfair slash and burn of home help hours, and well as reversing the cuts to rural schools and DEIS schools, and the dangerous cuts to guidance counsellors at second level. We also propose lifting the ban on recruitment in the garda?, as local garda services have already been stretched to the limit.

?Fianna F?il has worked out measures to exceed the Government?s one tax targets for next year, without slapping hard-pressed homeowners with hefty property taxes. We believe that this is not the time for a property tax, with so many homeowners in Donegal and across the country struggling to pay their mortgage.?

The party has also accused the Government of failing to tackle the deepening jobs crisis and to provide proper supports to small businesses in difficulty.

Deputy McConalogue said: ?Donegal has the highest rate of youth unemployment in the country, and the government?s jobs plans have had absolutely no impact on the jobs crisis in this region.

?We are proposing to increase the places in local employment schemes, in areas such as child care, home help and community renewal projects. We also propose a range of supports for local companies by tackling the burden of commercial rates, reforming the availability of credit and scrapping plans to push the cost of sick pay onto employers.?

?

Source: http://www.donegaldaily.com/2012/11/22/no-property-tax-under-our-budget-proposals-says-mcconalogue/

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Wednesday, November 14, 2012

Nash Finch settles sex discrimination complaint ? Business ...

Food wholesaler Nash Finch has settled complaints it discriminated against women at its Lumberton facility. Based in Minnesota, Nash Finch is the nation?s second largest food wholesaler and has received $14 million in federal contract payments since 2005.

The Department of Labor?s Office of Federal Contract Compliance Pro????grams (OFCCP) investigated complaints that the company was refusing to hire women for entry-level positions at its Lumberton plant. Under the settlement, Nash Finch will pay $188,500 in back wages and interest to 84 female job applicants. ?

The OFCCP investigated the company?s hiring practices from May 2005 to December 2006. It found the company failed to ensure qualified female job applicants received equal consideration for employment without regard to sex. That violates a federal executive order.

In addition to the monetary settlement, Nash Finch must offer jobs to 12 women who applied for jobs during the period the OFCCP investigated. It must also submit progress reports to the OFCCP for the next two years.

Note: Federal contractors face an additional layer of scrutiny when it comes to discrimination complaints. Proper training for employees in??volved in the hiring process will go a long way to preventing complaints.

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Thursday, November 8, 2012

Lafreniere Street shooting suspect booked by New Orleans police ...

New Orleans police have arrested one suspect and are searching for another in connection to a shooting outside of a bar in the 1500 block of Lafreniere Street last Sunday. Darryl Galle, 24, was booked with attempted first-degree murder and criminal damage to property after he was arrested for chasing down a 51-year-old man on Oct. 28 outside of PJ's Bar at the intersection of Lafreniere and Hamburg Streets, according to an arrest warrant filed in Orleans Parish Criminal District Court.

According to the record, the victim told police that a man named 'Yank', whom he believed had shot his son in 2002, was at the bar with Galle around 1:40 a.m. and that the two men turned their backs to him. The victim told cops he got up to leave the bar and was followed by both Galle and "Yank," whom police later identified as Clarence Glenn Walker, and started to run once he noticed both men following him.

Galle and Walker then allegedly began firing at the victim, shooting him three times. The victim, who later told police he felt a "sharp burning sensation" in his left thigh, upper back and upper right shoulder, escaped the scene by running to a nearby porch and hiding as he called the police.

Police recovered more than 32 spent 9 mm casings, and both suspects are believed to have been shooting a handgun. The shooting also damaged several cars and a business nearby.

Galle, who was identified by a detective working the case a member of the Young Gunners gang in the old St. Bernard Housing Development, was picked out of a photo lineup by the victim and taken into custody on Nov. 2.

Galle, whose bond was set at $355,000, is no stranger to local police. He has a slew of prior arrests, including drug-related offenses, burglary and armed robbery.

Police have obtained an arrest warrant for Walker, who was implicated though a Crimestopper's tip. He is described as a 32-year-old man with dreadlocks, approximately 5-foot-5 and weighing 325 to 350 pounds. He was last seen wearing dark clothing.

Source: http://www.nola.com/crime/index.ssf/2012/11/new_orleans_police_book_suspec_1.html

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Friday, November 2, 2012

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